New findings reported from G.R. Rossi and co-authors describe advances in immunotherapy.(Report)

According to a study from the United States, "Owing to the absence of alpha Gal epitopes in human cells and constant stimulation of the immune system by the symbiotic bacterial flora, humans develop high titers of natural antibodies against these epitopes. It has been demonstrated that syngeneic whole cell vaccines modified to express alpha Gal epitopes could be used to generate a potent anticancer vaccine."

"In this study, we tested whether allogeneic whole cell cancer vaccines modified to express alpha Gal epitopes would be effective for the treatment of murine melanoma. The alpha(1,3) galactosyltransferase (alpha GT) knockout mice (H-2(b/b)) with preexisting …